With the extensive application of radiotherapy in various cancers, its side effects in tissues adjacent to cancers are garnering much attention. Intestines are sensitive to irradiation due to its rapid proliferation, and irradiation-induced enteric inflammation is common in patients with pelvic peritoneal tumors. Sirt1, class III protein deacetylase, could lead to transcriptional repression of various inflammation-associated genes, and our previous study has proved its relationship with interleukin (IL)-1β. Here we show that resveratrol, the activator of Sirt1, could alleviate the bowel inflammation induced by irradiation and the expression of Sirt1 is consistent with the inflammation level. We further identified in vivo that Sirt1 repress the expression of IL-1β by the repression of NLR Family, Pyrin Domain Containing protein 3 (NLRP3) expression. In conclusion, this study confirms resveratrol acts against radiation-induced inflammatory bowel disease via NLRP-3 inflammasome repression in mice and supports Sirt1 as a potential biomarker and therapy target in intestinal radiation protection.

随着放疗在各种癌症中的广泛应用，其在癌旁组织中的副作用引起了广泛关注。肠道由于其快速增殖而对放射线敏感，并且在盆腔腹膜肿瘤患者中，放射线诱发的肠道炎症很常见。Sirt1，III类蛋白脱乙酰基酶，可能导致多种炎症相关基因的转录抑制，而我们先前的研究证明了其与白介素（IL）-1β的关系。在这里，我们显示白藜芦醇，Sirt1的激活剂，可以减轻辐射引起的肠炎症，Sirt1的表达与炎症水平相符。我们进一步在体内发现Sirt1通过抑制NLR家族，含有蛋白3的Pyrin域（NLRP3）表达来抑制IL-1β的表达。