Psoriasis is an immune-mediated disease, with genetic background and triggering environmental factors; however, several gaps are still present in understanding the intertwined relationship between these elements. Epigenetic mechanisms, including microRNAs (miRNAs), play an important role in the pathogenesis of psoriasis. The relationship between interleukin (IL)-17, a key cytokine in psoriasis, and these epigenetic mechanisms still needs to be elucidated. This study aimed at assessing the expression of miRNA-155, miRNA-210, and miRNA-20b in skin and sera of psoriasis patients in relation to IL-17 levels. For 20 psoriasis patients and 20 matching controls, the expression of miRNA-155, miRNA-210, and miRNA-20b was assessed using real-time polymerase chain reaction (RT-PCR), whereas IL-17/IL-17A levels were measured using quantitative enzyme-linked immunosorbent assay (ELISA) technique. MiRNA-155 expression was significantly higher in lesional skin compared to controls (P = 0.001). MiRNA-210 expression was significantly higher in both, lesional skin (P = 0.010) and sera of patients (P = 0.001) in comparison with controls. A statistically significant positive correlation was found between serum miRNA-210 expression and serum levels of IL-17/IL-17A (P = 0.010, rs = 0.562). MiRNA-20b lesional and non-lesional expression was significantly higher than controls (P < 0.001; P = 0.018). In conclusion, the expression of miRNA-155, miRNA-210, and miRNA-20b is exaggerated in psoriasis and they may be involved in disease pathogenesis. A possible relationship between miRNA-210 and IL-17 may be suggested; however, further studies are still needed to verify this relation.

牛皮癣是一种免疫介导的疾病，具有遗传背景和触发环境因素。但是，在理解这些要素之间的相互联系方面仍然存在一些差距。表观遗传机制，包括microRNA（miRNA），在牛皮癣的发病机理中起重要作用。银屑病中的关键细胞因子白介素（IL）-17与这些表观遗传机制之间的关系仍然有待阐明。这项研究旨在评估与IL-17水平相关的牛皮癣患者皮肤和血清中miRNA-155，miRNA-210和miRNA-20b的表达。对于20个牛皮癣患者和20个匹配的对照，使用实时聚合酶链反应（RT-PCR）评估了miRNA-155，miRNA-210和miRNA-20b的表达，而IL-17 / IL-17A的水平是使用定量酶联免疫吸附测定（ELISA）技术测量的。与对照组相比，病变皮肤中的MiRNA-155表达明显更高（P  = 0.001）。 与对照组相比 ，患者病灶皮肤（P = 0.010）和血清（P = 0.001）中的miRNA-210表达均显着较高。血清miRNA-210表达与血清IL-17 / IL-17A水平之间存在统计学意义的正相关（P  = 0.010，rs = 0.562）。MiRNA-20b的病灶和非病灶表达明显高于对照组（P  <0.001；P  = 0.018）。总之，牛皮癣中miRNA-155，miRNA-210和miRNA-20b的表达被夸大了，它们可能与疾病的发病机理有关。可能暗示了miRNA-210和IL-17之间可能存在的关系。但是，仍然需要进一步的研究来验证这种关系。