This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. In seven academic centers, 550 cariously exposed pulps were included and randomly allocated into PMTA (n = 188), PCEM (n = 194), or RCT (n = 168) arms. Preoperative “Pain Intensity” (PI) on Numerical Rating Scale and postoperative PIs until day 7 were recorded. Patients’ demographic and pre-/intra-/postoperative factors/conditions were recorded/analysed. The arms were homogeneous in terms of demographics. The mean preoperative PIs were similar (), the mean sum PIs recorded during 10 postoperative intervals were comparable (), and the trend/changes in pain relief were parallel () in all study arms. The incidences of preoperative moderate-severe pain in RCT, PMTA, and PCEM arms were 56.5%, 55.7%, and 56.7%, which after 24 hours considerably decreased to 13.1%, 10.6%, and 12.9%, respectively (). The time span of endodontic procedures was statistically different; RCT = 69.73, PMTA = 35.37, and PCEM = 33.62 minutes (). Patients with greater preoperative pain, symptomatic apical periodontitis, or presence of PDL widening suffered more pain (, 0.035, and 0.023, resp.); however, other pre-/intra-/postoperative factors/conditions were comparable. Pulpotomy with MTA/CEM and RCT demonstrate comparable and effective postoperative pain relief.

中文翻译：

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牙髓切开术对成熟牙齿进行牙髓切开术或根管治疗后的牙髓后疼痛：多中心随机对照试验。

这项等效的随机临床试验旨在比较根管治疗（RCT）与三叶矿物矿物质（PMTA）或富含钙的混合物（PCEM）切牙在恒久成熟牙齿中的术后疼痛。在七个学术中心，包括550个龋齿暴露的牙髓，并随机分配到PMTA（n  = 188），PCEM（n  = 194）或RCT（n  = 168）组中。记录数字等级量表的术前“疼痛强度”（PI）和术后第7天的术后PI。记录/分析患者的人口统计学和术前/术中/术后因素/情况。从人口统计的角度来看，武器是同质的。术前平均PIs相似（），在10个术后间隔期间记录的平均PI值具有可比性（），并且疼痛缓解的趋势/变化是平行的（）。RCT，PMTA和PCEM臂术前中度重度疼痛的发生率分别为56.5％，55.7％和56.7％，在24小时后分别分别降至13.1％，10.6％和12.9％（）。牙髓手术的时间跨度有统计学差异；RCT = 69.73，PMTA = 35.37，PCEM = 33.62分钟（）。术前疼痛较大，有症状的根尖性牙周炎或PDL增宽的患者遭受的疼痛更大（， 0.035和0.023）。然而，其他术前/术中/术后因素/病情是可比的。用MTA / CEM和RCT进行切开术显示出可比且有效的术后疼痛缓解。