The sarcomeric proteins control the movement of cells in diverse species, whereas the deregulation can induce tumours in model organisms and occurs in human carcinomas. Sarcomeric proteins are recognized as oncogene and related to tumor cell metastasis. Recent insights into their expressions and functions have led to new cancer therapeutic opportunities. In this review, we appraise the evidence for the sarcomeric proteins as cancer genes and discuss cancer-relevant biological functions, potential mechanisms by which sarcomeric proteins activity is altered in cancer.

中文翻译：

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肌节蛋白在癌症中的表达及其机制。

肌节蛋白控制着各种物种中细胞的运动，而放松调节则可以在模型生物中诱发肿瘤，并发生在人类癌症中。肌节蛋白被认为是癌基因，与肿瘤细胞转移有关。最近对其表达和功能的见解导致了新的癌症治疗机会。在这篇综述中，我们评估了肌节蛋白作为癌症基因的证据，并讨论了与癌症有关的生物学功能，肌节蛋白活性在癌症中改变的潜在机制。