Primary immune thrombocytopenia (ITP) is an autoimmune disease. However, the molecular mechanisms underlying ITP remained to be further investigated. In the present study, we analyzed a series of public datasets (including GSE43177 and GSE43178) and identified 468 upregulated mRNAs, 272 downregulated mRNAs, 134 upregulated lncRNAs, 23 downregulated lncRNAs, 29 upregulated miRNAs, and 39 downregulated miRNAs in ITP patients. Then, we constructed protein-protein interaction networks, miRNA-mRNA and lncRNA coexpression networks in ITP. Bioinformatics analysis showed these genes regulated multiple biological processes in ITP, such as mRNA nonsense-mediated decay, translation, cell-cell adhesion, proteasome-mediated ubiquitin, and mRNA splicing. We thought the present study could broaden our insights into the mechanism underlying the progression of ITP and provide a potential biomarker for the prognosis of ITP.

中文翻译：

---

免疫性血小板减少症中与lncRNA相关的ceRNA网络的系统鉴定。

原发性免疫性血小板减少症（ITP）是一种自身免疫性疾病。但是，ITP的分子机制尚待进一步研究。在本研究中，我们分析了一系列公共数据集（包括GSE43177和GSE43178），并在ITP患者中鉴定了468个上调的mRNA，272个下调的mRNA，134个上调的lncRNA，23个下调的lncRNA，29个上调的miRNA和39个下调的miRNA。然后，我们在ITP中构建了蛋白质-蛋白质相互作用网络，miRNA-mRNA和lncRNA共表达网络。生物信息学分析表明，这些基因调节了ITP中的多个生物过程，例如mRNA无意义介导的衰变，翻译，细胞间粘附，蛋白酶体介导的泛素和mRNA剪接。