The demand for new biomaterials in several biomedical applications, such as regenerative engineering and drug delivery, has increased over the past two decades due to emerging technological advances in biomedicine. Degradable polymeric biomaterials continue to play a significant role as scaffolding materials and drug devices. Polyphosphazene platform is a subject of broad interest, as it presents an avenue for attaining versatile polymeric materials with excellent structure and property tunability, and high functional diversity. Macromolecular substitution enables the facile attachment of different organic groups and drug molecules to the polyphosphazene backbone for the development of a broad class of materials. These materials are more biocompatible than traditional biomaterials, mixable with other clinically relevant polymers to obtain new materials and exhibit unique erosion with near-neutral degradation products. Hence, polyphosphazene represents the next generation of biomaterials. In this review, the authors systematically discuss the synthetic design, structure-property relationships, and the promising potentials of polyphosphazenes in regenerative engineering and drug delivery.

中文翻译：

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聚磷腈聚合物：用于再生工程和治疗药物递送的下一代生物材料

由于生物医学的新兴技术进步，在过去二十年中，再生工程和药物输送等多种生物医学应用对新型生物材料的需求有所增加。可降解聚合物生物材料作为支架材料和药物装置继续发挥重要作用。聚磷腈平台是一个受到广泛关注的主题，因为它为获得具有优异结构和性能可调性以及高功能多样性的多功能聚合物材料提供了途径。大分子取代使不同的有机基团和药物分子能够轻松地连接到聚磷腈骨架上，以开发多种材料。这些材料比传统生物材料更具生物相容性，可与其他临床相关聚合物混合以获得新材料，并表现出具有近中性降解产物的独特侵蚀。因此，聚磷腈代表了下一代生物材料。在这篇综述中，作者系统地讨论了聚磷腈在再生工程和药物输送中的合成设计、结构-性能关系和有前景的潜力。