The purpose of this study was to identify the long-term effect of chemical exposure on the liver. Laboratory tests included alanine aminotransferase (ALT) dosage and oxidative stress tests, such as thiobarbituric acid reactive substances in plasma and superoxide dismutase (SOD) and glutathione S-transferase analysis in erythrocytes. The cross-sectional study comprised 70 workers, 30 of them exposed to organic solvents and 40 not exposed. All those exposed presented at least 5 years of exposure to solvents. Hepatitis B and C, known hepatic disease, comorbidities, use of alcohol, illicit drugs or hepatotoxic medications, smoking, body mass index >30, female sex and age (<18 or >65) were excluded from the sample. Results indicated that elevated ALT was more frequent in the exposed group compared to controls: 33% vs. 10.5%, with a statistical significance (p < 0.05). Thiobarbituric acid reactive substances were significantly elevated (p < 0.01) in the exposed group in comparison to controls. Antioxidant enzymes were more elevated in the exposed group compared to controls: SOD 7.29 (4.30-8.91) USOD/mg of protein vs. 3.48 (2.98-5.28) USOD/mg of protein and GST 2.57 µmol/min/mg of protein (1.80-4.78) vs. 1.81 µmol/min/mg of protein (1.45- 2.30) µM/min/mg of protein. The results suggest an association between exposure to organic solvents and hepatotoxicity.

这项研究的目的是确定化学暴露对肝脏的长期影响。实验室测试包括丙氨酸氨基转移酶（ALT）剂量和氧化应激测试，例如血浆中的硫代巴比妥酸反应性物质以及红细胞中的超氧化物歧化酶（SOD）和谷胱甘肽S-转移酶分析。横断面研究由70名工人组成，其中30名暴露于有机溶剂中，40名未暴露于有机溶剂中。所有这些暴露者均至少有5年接触溶剂的经历。样本中不包括乙型和丙型肝炎，已知的肝病，合并症，饮酒，非法药物或肝毒性药物，吸烟，体重指数> 30，性别和年龄（<18或> 65）。结果表明，与对照组相比，暴露组的ALT升高更为频繁：33％比10.5％，具有统计学意义（p <0.05）。与对照组相比，暴露组的硫代巴比妥酸反应性物质显着升高（p <0.01）。与对照组相比，暴露组的抗氧化酶水平更高：SOD 7.29（4.30-8.91）USOD / mg蛋白质vs. 3.48（2.98-5.28）USOD / mg蛋白质和GST 2.57 µmol / min / mg蛋白质（1.80 -4.78）vs. 1.81 µmol / min / mg的蛋白质（1.45- 2.30）µM / min / mg的蛋白质。结果表明，暴露于有机溶剂与肝毒性之间存在关联。28）USOD / mg蛋白质和GST 2.57 µmol / min / mg蛋白质（1.80-4.78）对1.81 µmol / min / mg蛋白质（1.45- 2.30）µM / min / mg蛋白质。结果表明，暴露于有机溶剂与肝毒性之间存在关联。28）USOD / mg蛋白质和GST 2.57 µmol / min / mg蛋白质（1.80-4.78）对1.81 µmol / min / mg蛋白质（1.45- 2.30）µM / min / mg蛋白质。结果表明，暴露于有机溶剂与肝毒性之间存在关联。