Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly with a pathogenesis that remains unclear. We aimed to explore its pathogenesis through plasma integrated metabolomics and proteomics analysis. The clinical data of consecutively recruited PD patients and healthy controls were assessed. Fasting plasma samples were obtained and analyzed using metabolomics and proteomics methods. After that, differentially expressed metabolites and proteins were identified for further bioinformatics analysis. No significant difference was found in the clinical data between these two groups. Eighty-three metabolites were differentially expressed in PD patients identified by metabolomics analysis. These metabolites were predominately lipid and lipid-like molecules (63%), among which 25% were sphingolipids. The sphingolipid metabolism pathway was enriched and tended to be activated in the following KEGG pathway analysis. According to the proteomics analysis, forty proteins were identified to be differentially expressed, seven of which were apolipoproteins. Furthermore, five of the six top ranking Gene Ontology terms from cellular components and eleven of the other fourteen Gene Ontology terms from biological processes were directly associated with lipid metabolism. In KEGG pathway analysis, the five enriched pathways were also significantly related with lipid metabolism (p < 0.05). Overall, Parkinson’s disease is associated with plasma lipid metabolic disturbance, including an activated sphingolipid metabolism and decreased apolipoproteins.

帕金森氏病（PD）是老年人常见的神经退行性疾病，其发病机制尚不清楚。我们旨在通过血浆综合代谢组学和蛋白质组学分析探索其发病机理。评估了连续招募的PD患者和健康对照者的临床数据。获得空腹血浆样品，并使用代谢组学和蛋白质组学方法进行分析。之后，鉴定出差异表达的代谢物和蛋白质，以进行进一步的生物信息学分析。两组之间的临床数据没有发现显着差异。通过代谢组学分析鉴定的PD患者中83种代谢物差异表达。这些代谢物主要是脂质和类脂质分子（63％），其中25％是鞘脂。在以下KEGG途径分析中，鞘脂代谢途径被富集并倾向于被激​​活。根据蛋白质组学分析，鉴定出40种差异表达的蛋白质，其中7种是载脂蛋白。此外，来自细胞成分的六个顶级基因本体术语中的五个与来自生物过程的其他十四个基因本体术语中的十一个与脂质代谢直接相关。在KEGG通路分析中，这五种富集的通路也与脂质代谢显着相关（来自细胞成分的六个排名最高的基因本体术语中的五个与来自生物过程的其他十四个基因本体术语中的十一个与脂质代谢直接相关。在KEGG通路分析中，这五种富集的通路也与脂质代谢显着相关（来自细胞成分的六个排名最高的基因本体术语中的五个与来自生物过程的其他十四个基因本体术语中的十一个与脂质代谢直接相关。在KEGG通路分析中，这五种富集的通路也与脂质代谢显着相关（p<0.05）。总体而言，帕金森氏病与血浆脂质代谢紊乱有关，包括激活的鞘脂代谢和载脂蛋白减少。