Reversible splenial lesion syndrome (RESLES) is a single-stage non-specific syndrome with unclear pathogenesis. There has been no report on answer delay in patients with RESLES. We report a female patient who was admitted to our department for mixed aphasia accompanied by cognitive impairment. During the rapid improvement of aphasia, there was a clear phase of language output response delay accompanied by resolution of imaging lesions. We analyzed the course and the examination results of the patient and speculated the cause and pathogenesis. RESLES-relevant knowledge was systematically reviewed, which will help doctors in the classification of cerebral function and the diagnosis of RESLES. The specific language and cognitive impairment may be associated with the damage of contact fibers in the bilateral primary and secondary sensory and motor cortices.

中文翻译：

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语言障碍可逆性脾病变综合征的临床及影像学表现

可逆性脾脏病变综合征（RESLES）是一种单阶段的非特异性综合征，发病机理尚不清楚。尚无关于RESLES患者回答延迟的报道。我们报告了一位女性患者，该患者因混合性失语症并伴有认知障碍而入院。在失语症的快速改善过程中，语言输出反应延迟明显，同时伴有影像学病变的消退。我们分析了患者的病程和检查结果，并推测了病因和发病机理。对RESLES相关知识进行了系统的回顾，这将有助于医生进行脑功能的分类和RESLES的诊断。