Oxidative stress, abnormal fatty acid metabolism, and impaired gut microbiota play a serious role in the pathology of autism. The use of dietary supplements to improve the core symptoms of autism is a common therapeutic strategy. The present study analyzed the effects of oral supplementation with Novavit, a multi-ingredient supplement, on ameliorating oxidative stress and impaired lipid metabolism in a propionic acid (PPA)-induced rodent model of autism. Male western albino rats were divided into three groups. The first group is the control, the second group was given an oral neurotoxic dose of PPA (250 mg/kg body weight/day) for 3 days and then received buffered saline until the end of the experiment. The third group received Novavit (70 mg/kg body weight/day for 30 days after the 3-day PPA treatment). Markers of oxidative stress and impaired fatty acid metabolism were measured in brain homogenates obtained from each group. Novavit modulation of the gut microbiota was also evaluated. While PPA induced significant increases in lipid peroxides and 5-lipoxygenase, together with significantly decreased glutathione, and cyclooxygenase 2, oral supplementation with Novavit ameliorated PPA-induced oxidative stress and impaired fatty acid metabolism. Our results showed that the presence of multivitamins, coenzyme Q10, minerals, and colostrum, the major components of Novavit, protects against PPA-induced neurotoxicity.

中文翻译：

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Novavit改善丙酸神经毒性的功效


氧化应激、脂肪酸代谢异常和肠道微生物群受损在自闭症病理学中发挥着重要作用。使用膳食补充剂来改善自闭症的核心症状是一种常见的治疗策略。本研究分析了口服补充 Novavit（一种多成分补充剂）对改善丙酸 (PPA) 诱导的自闭症啮齿动物模型氧化应激和脂质代谢受损的影响。雄性西方白化大鼠被分为三组。第一组为对照组，第二组口服神经毒性剂量的 PPA（250 mg/kg 体重/天），持续 3 天，然后接受缓冲盐水直至实验结束。第三组接受 Novavit（在 3 天的 PPA 治疗后，每天 70 毫克/公斤体重，持续 30 天）。在从每组获得的脑匀浆中测量氧化应激和脂肪酸代谢受损的标志物。还评估了 Novavit 对肠道微生物群的调节。虽然 PPA 导致脂质过氧化物和 5-脂氧合酶显着增加，同时谷胱甘肽和环加氧酶 2 显着降低，但口服 Novavit 可以改善 PPA 诱导的氧化应激和脂肪酸代谢受损。我们的结果表明，Novavit 的主要成分复合维生素、辅酶 Q10、矿物质和初乳的存在可以防止 PPA 引起的神经毒性。