The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses. However, in clinical practice, to gather enough information to formulate a diagnosis, multiple biomarkers are normally quantified from the same biological sample simultaneously. Therefore, it is critically important to translate lab-based bioelectronic devices based on electrolyte gated thin-film transistor technology into a cost-effective portable multiplexing array prototype. In this perspective, the assessment of cost-effective manufacturability represents a crucial step, with specific regard to the optimization of the bio-functionalization protocol of the transistor gate module. Hence, we have assessed, using surface plasmon resonance technique, a sustainable and reliable cost-effective process to successfully bio-functionalize a gold surface, suitable as gate electrode for wide-field bioelectronic sensors. The bio-functionalization process herein investigated allows to reduce the biorecognition element concentration to one-tenth, drastically impacting the manufacturing costs while retaining high analytical performance.

中文翻译：

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宽带生物传感平台的金生物功能化评估。

生物电子设备在生物传感领域的技术潜力的不断提高，将为临床医生提供可靠的工具，可用于量化生物标记直至单个分子。最终，医生将能够确定疾病开始的那一刻，这对生活质量产生了巨大影响，并减少了医疗保健费用。然而，在临床实践中，为了收集足够的信息来制定诊断，通常通常从同一生物样品中同时定量多个生物标志物。因此，将基于电解质门控薄膜晶体管技术的基于实验室的生物电子设备转换为具有成本效益的便携式多路复用阵列原型至关重要。从这个角度来看，对于具有成本效益的可制造性的评估是至关重要的一步，特别是在优化晶体管门模块的生物功能化协议方面。因此，我们使用表面等离子体共振技术评估了一种可持续且可靠，具有成本效益的过程，以成功地对金表面进行生物功能化，该金表面适合用作宽场生物电子传感器的栅电极。本文研究的生物功能化过程可将生物识别元素的浓度降低至十分之一，从而在保持高分析性能的同时，极大地影响了制造成本。一种可持续且可靠，具有成本效益的方法，可以成功地对金表面进行生物功能化，适合作为宽视野生物电子传感器的栅电极。本文研究的生物功能化过程可将生物识别元素的浓度降低至十分之一，在保持高分析性能的同时，极大地影响了制造成本。一种可持续且可靠，具有成本效益的方法，可以成功地对金表面进行生物功能化，适合作为宽视野生物电子传感器的栅电极。本文研究的生物功能化过程可将生物识别元素的浓度降低至十分之一，从而在保持高分析性能的同时，极大地影响了制造成本。