The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap® and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan® and Bediol® macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan® and Bediol® oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol® and Bedrocan® was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.

中文翻译：

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脂质来源对医用大麻油制剂品质性状的影响

研究了使用两种脂质来源的可行性及其对 3 个月冷藏储存期间医用大麻油制剂中大麻素谱、萜烯指纹和降解产物的影响。LCHRMS-Orbitrap® 和 HS-SPME 与 GC-MS 联用，用于研究 Bedrocan® 和 Bediol® 浸渍油中的靶向和非靶向大麻素、萜烯和脂质降解产物。关于 90 天储存期间的大麻素趋势，PhEur 级橄榄油 (O​​OPH) 和中链甘油三酯油 (MCT 油) 之间没有差异，而在前 60 天，Bedrocan® 中的制剂稳定性良好和 Bediol® 油。与橄榄油相比，MCT 脂质源提取了显着浓度的萜烯。萜烯表现出不同的情况，因为 MCT 油在保质期内显示出所有化合物的最强提取能力和保存趋势。MCT 配方中萜烯在整个储存期内保持稳定，而在橄榄油中观察到在 Bediol® 和 Bedrocan® 中的 15 天和 30 天后萜烯显着下降。因此，与用于提取医用大麻以用于治安制剂的橄榄油相比，MCT 油可以被认为是更合适的脂质来源。