^‡ These authors contributed equally.

In memory of Prof. Dr. Rolf Huisgen

Abstract

A halogen–lithium exchange in the presence of MgCl₂·LiCl on a broad range of heterocyclic scaffolds using a commercial flow set-up with nBuLi as exchange reagent is reported. The resulting diheteroarylmagnesium species were subsequently trapped with various electrophiles, such as ketones, aldehydes, allylic bromides, or disulfides affording functionalized heterocycles. A scale-up was performed by simply increasing the run-time without further optimizations.

中文翻译：

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卤代锂交换功能化杂芳基卤化物并随后用MgCl2·LiCl原位连续捕集制备二有机镁试剂

^‡这些作者贡献相同。

纪念Rolf Huisgen教授

抽象

卤素-锂交换在氯化镁存在₂ ·氯化锂在广泛杂环支架的使用商业流的建立与Ñ丁基锂作为交换试剂进行报告。随后用各种亲电试剂（例如酮，醛，烯丙基溴化物或二硫化物）捕获所得的二杂芳基镁物质，得到官能化的杂环。仅通过增加运行时间即可进行放大，而无需进一步优化。