The butyrophilins (BTNs) represent a unique family of immunoglobulin. They were considered to be involved in milk lactation after their discovery in 1981. With the development of research, an increasing number of research revealed that BTNs play important roles in immune regulation [1992–2019]. Our research aimed to summarize the BTN research status and their relationship with lung cancers and breast cancers by bibliometrics and bioinformatics methods. Our results indicate that the researches on immune-regulatory functions of BTNs gradually developed from 1992 to 2006, whereas they increased quickly after 2007. There are international cooperations among 56 countries, of which the United States is the most active one with the highest number of studies as well as highest citations. By coauthorship and cocitation analysis, we showed that Adrian Hayday, who is active in γδ T-cell field, was an active author in BTN publications with average year of 2015 and led a subfield. By keywords co-occurrence analysis, we found that γδ T cell, which is an important cancer immune regulator, is one important hotspot. Finally, we found that several BTN members' expression levels were significantly correlated with prognosis of lung cancer and breast cancer patients. Thus, these BTNs might play immune regulatory effects and could serve as potential biomarkers for cancer.

酪氨酸蛋白（BTN）代表独特的免疫球蛋白家族。在1981年发现它们后，它们被认为参与了泌乳。随着研究的发展，越来越多的研究表明BTN在免疫调节中起着重要的作用[1992-2019]。我们的研究旨在通过文献计量学和生物信息学方法总结BTN的研究现状及其与肺癌和乳腺癌的关系。我们的结果表明，关于BTN免疫调节功能的研究从1992年到2006年逐渐发展，而在2007年之后迅速增加。56个国家之间开展了国际合作，其中美国是最活跃的国家，数量最多。研究以及最高的引文。通过合著和引文分析，我们发现活跃于γδT细胞领域的Adrian Hayday是BTN出版物的活跃作者，平均年份为2015年，并领导了一个子领域。通过关键词共现分析，我们发现γδT细胞是重要的癌症免疫调节剂，它是重要的癌症免疫调节剂。最后，我们发现一些BTN成员的表达水平与肺癌和乳腺癌患者的预后显着相关。因此，这些BTN可能发挥免疫调节作用，并可能成为癌症的潜在生物标记。表达水平与肺癌和乳腺癌患者的预后显着相关。因此，这些BTN可能发挥免疫调节作用，并可能成为癌症的潜在生物标记。表达水平与肺癌和乳腺癌患者的预后显着相关。因此，这些BTN可能发挥免疫调节作用，并可能成为癌症的潜在生物标记。