Sjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression of MHC II molecules on glandular epithelial cells. In contrast to the well-characterized clinical and immunological features, the etiology and pathogenesis of SS remain largely unknown. Animal models are powerful research tools for elucidating the pathogenesis of human diseases. To date, many mouse models of SS, including induced models, in which disease is induced in mice, and genetic models, in which mice spontaneously develop SS-like disease, have been established. These mouse models have provided new insight into the pathogenesis of SS. In this review, we aim to provide a comprehensive overview of recent advances in the field of experimental SS.

干燥综合征（SS）是一种复杂的类风湿病，主要影响外分泌腺，导致口干症（口干）和干眼症（干眼）。SS的特点是自身抗体，外分泌腺浸润以及MHC II分子在腺上皮细胞上的异位表达。与特征明确的临床和免疫学特征相反，SS的病因和发病机制仍然未知。动物模型是用于阐明人类疾病发病机理的强大研究工具。迄今为止，已经建立了许多SS小鼠模型，包括在小鼠中诱发疾病的诱导模型，以及其中小鼠自发性发展SS样疾病的遗传模型。这些小鼠模型为SS的发病机理提供了新的见解。在这篇评论中