Efficacy of photodynamic therapy (PDT) with hypericin was compared using two cell lines in monolayer culture. Photokilling was substantially impaired in the A549 (human‐derived lung tumor) when compared with the 1c1c7 murine hepatoma. The efficacy of PDT with regard to photokilling was correlated with the steady‐state intracellular hypericin concentration. There was otherwise no difference in subcellular targets or the pathway to cell death: paraptosis. In a prior study involving cell lines derived from patients with head and neck cancer, differences in response to PDT had shown no correlation with photosensitizer uptake.

中文翻译：

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金丝桃素积累作为 PDT 疗效的决定因素

使用单层培养中的两种细胞系比较了使用金丝桃素的光动力疗法 (PDT) 的功效。与 1c1c7 鼠肝癌相比，A549（人源性肺肿瘤）中的光致杀伤显着受损。PDT 在光杀伤方面的功效与稳态细胞内金丝桃素浓度相关。在其他方面，亚细胞靶标或细胞死亡途径没有差异：paraptosis。在先前涉及来自头颈癌患者的细胞系的研究中，对 PDT 的反应差异与光敏剂摄取无关。