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Intact vagal gut‐brain signalling prevents hyperphagia and excessive weight gain in response to high‐fat high‐sugar diet
Acta Physiologica ( IF 5.6 ) Pub Date : 2020-06-30 , DOI: 10.1111/apha.13530
Molly McDougle 1, 2, 3 , Danielle Quinn 3 , Charlene Diepenbroek 3, 4 , Arashdeep Singh 1, 2 , Claire de la Serre 5 , Guillaume de Lartigue 1, 2, 3, 4
Affiliation  

The tools that have been used to assess the function of the vagus nerve lack specificity. This could explain discrepancies about the role of vagal gut‐brain signalling in long‐term control of energy balance. Here we use a validated approach to selectively ablate sensory vagal neurones that innervate the gut to determine the role of vagal gut‐brain signalling in the control of food intake, energy expenditure and glucose homoeostasis in response to different diets.

中文翻译:

完整的迷走神经肠-脑信号可防止高脂肪高糖饮食引起的食欲过盛和体重过度增加

用于评估迷走神经功能的工具缺乏特异性。这可以解释关于迷走神经肠脑信号在长期控制能量平衡中的作用的差异。在这里,我们使用一种经过验证的方法来选择性地消融支配肠道的感觉迷走神经元,以确定迷走神经肠脑信号在控制食物摄入、能量消耗和葡萄糖稳态中的作用,以响应不同的饮食。
更新日期:2020-06-30
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