Striatal connectivity in pre-manifest Huntington's disease is differentially affected by disease burden.,European Journal of Neurology

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Striatal connectivity in pre-manifest Huntington's disease is differentially affected by disease burden.
European Journal of Neurology ( IF 4.5 ) Pub Date : 2020-06-30 , DOI: 10.1111/ene.14423
L Pini ₁ , K Youssov _{2,

3,

4,

5} , F Sambataro ₁ , A-C Bachoud-Levi _{2,

3,

4,

5} , A Vallesi _{1,

6} , C Jacquemot _{2,

3,

4}

Affiliation

Different amounts of cumulative exposure to the toxic mutant form of the huntingtin protein might underlie the distinctive pattern of striatal connectivity in pre‐manifest Huntington’s disease (pre‐HD). The aim of this study was to investigate disease‐burden‐dependent cortical‐striatal and subcortical‐striatal loops at different pre‐HD stages.

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