Acamprosate is a medication used to treat alcohol dependence. Therapeutic drug monitoring is important in drugs for the treatment of substance‐related disorders. Therefore, in this study, a new selective, very simple and rapid ultra‐performance liquid chromatography–tandem mass spectrometer method was developed for the therapeutic drug monitoring of acamprosate. The developed method allows the determination of acamprosate in human plasma. The method was validated in terms of selectivity and linearity, which was in the range of 100–1,200 ng/ml for acamprosate. Intra‐assay and inter‐assay accuracy and precision were within the acceptable limits of the Eueopean Medicines Agency guideline. The lower limit of quantitation was 100 ng/ml for acamprosate. The developed method was successfully applied for therapeutic drug monitoring in patient plasma samples.

中文翻译：

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通过UPLC-MS / MS测定人血浆中的阿坎酸：在治疗药物监测中的应用。

阿坎酸是一种用于治疗酒精依赖的药物。药物治疗监测在药物治疗与物质有关的疾病中很重要。因此，在这项研究中，开发了一种新的选择性，非常简单和快速的超高效液相色谱串联质谱仪方法，用于对阿坎酸的治疗药物进行监测。开发的方法可以测定人血浆中的阿坎酸。该方法在选择性和线性方面均得到验证，对于阿坎酸而言，其范围为100–1,200 ng / ml。批内和批间准确性和精密度均在欧洲药品管理局准则的可接受范围内。阿坎酸的定量下限为100 ng / ml。