Background

Advanced glycation end products (AGEs) play a crucial role in the onset, progression, and propagation of both macroangiopathy and microangiopathy complications associated with diabetes mellitus, while some dietary flavonoids and their derivatives were proved to be potential in the controlling of AGEs during the past decades.

Scope and approach

In this review, the multifunctional effects of flavonoids were summarized in the aspect of inhibiting the formation of AGEs and attenuating AGEs-induced harmful effects.

Key findings and conclusions: A multitude of plant-derived flavonoids have been examined of their antiglycative capability in in vitro models, while glycosylation and methylation/methoxylation of flavonoids might decrease the ability of aglycones. Furthermore, the attenuation of AGEs-induced damages by flavonoids were mainly targeted on the receptor of AGEs (RAGE) and through the prevention of MAPKs/NF-κB or TGF-β1 signaling pathway. Besides, during the inhibition of AGEs formation, flavonoids can trap reactive di-carbonyl species (RCS) and form new adducts. Some of these flavonoid-RCS adducts were further proved to possess bioactivities in foods and biological systems.

中文翻译：

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黄酮类化合物对高级糖基化终产物（AGEs）形成和AGEs诱导的有害作用的多功能作用

背景

晚期糖基化终末产物（AGEs）在与糖尿病相关的大血管病变和微血管病变并发症的发作，进展和传播中起着至关重要的作用，而在过去，一些饮食类黄酮及其衍生物被证明具有控制AGEs的潜力。几十年。

范围和方法

本文综述了类黄酮在抑制AGEs形成和减轻AGEs诱导的有害作用方面的多功能作用。

主要发现和结论：在体外模型中已研究了多种植物类黄酮的抗糖基化能力，而类黄酮的糖基化和甲基化/甲氧基化可能会降低糖苷配基的能力。此外，类黄酮对AGEs诱导的损伤的减轻主要针对AGEs受体（RAGE），并通过预防MAPKs /NF-κB或TGF-β1信号通路来实现。此外，在抑制AGEs形成过程中，类黄酮可以捕获反应性二羰基物质（RCS）并形成新的加合物。这些类黄酮-RCS加合物中的一些被进一步证明在食品和生物系统中具有生物活性。