In this study, we reported a novel highly ordered nano-micro hierarchical structure on flexible polydimethylsiloxane (PDMS) layer as a SERS stamp for ultrasensitive detection, which can generate huge SERS signals with silver nanoparticles (AgNPs) owing to a multiscale coupling electromagnetic enhancement mechanism. Highly ordered nanowrinkles were prepared by oxygen plasma and stretching treatment of PDMS. Indeed, a tactfully designed zigzag micropattern can efficiently reduce the fracture defects of nanowrinkles because the contraction force can be lessened at releasing step. This proposed substrate has high reproducibility and uniformity that the relative standard deviation (RSD) was below 7 %. With uniform hot spots on this novel flexible SERS substrate, 2, 4, 6-trinitrotoluene (TNT) residues can be detected on coarse surfaces of target item. A molecule interaction mechanism of Meisenheimer complex was applied to combine AgNPs and nanowrinkles for highly sensitive detecting TNT. The detection sensitivity of TNT molecules can achieve a limit of 10⁻¹³ mol L⁻¹. Additionally, a practical application was proceeded by wiping the cloth bag to detect the TNT residues with a limit of 10⁻⁹ mol L⁻¹. This demonstrated stamp-like flexible substrate showed unique SERS activity and non-invasive sampling, it is expected to be a promising tool for the explosive, drug and environmental pollutant in field-detection.

在这项研究中，我们报道了在柔性聚二甲基硅氧烷（PDMS）层上的一种新颖的高度有序的纳米微分层结构，作为用于超灵敏检测的SERS邮票，由于多尺度耦合电磁增强机制，它可以与银纳米颗粒（AgNP）产生巨大的SERS信号。通过氧等离子体和PDMS的拉伸处理制备高度有序的纳米皱纹。实际上，因为可以在释放步骤中减小收缩力，所以设计巧妙的之字形微图案可以有效地减少纳米皱纹的断裂缺陷。该提议的基材具有较高的重现性和均匀性，相对标准偏差（RSD）低于7％。在这种新颖的柔性SERS基板上具有均匀的热点，可以在目标物品的粗糙表面上检测到2，4，6-三硝基甲苯（TNT）残留物。迈森海默复合物的分子相互作用机制被用于结合AgNPs和纳米皱纹，以高灵敏度检测TNT。TNT分子的检测灵敏度可以达到10的极限^-13  mol L ^-1。另外，通过擦拭布袋进行实际应用以检测​​TNT残基，其极限为10 ^-9  mol L ^-1。这种经过展示的类似邮票的柔性基材显示出独特的SERS活性和无创采样，有望成为现场检测中爆炸物，药物和环境污染物的有前途的工具。