Rasagiline mesylate is used as first line agent for early management of Parkinson's disease but its water soluble nature creates hurdles to cross blood brain barrier also its low oral bioavailability and rapid elimination requires frequent dosing. Thus present study aims to prepare rasagiline mesylate-nanoparticles (RM-NPs) loaded gellan gum transdermal film for non-invasive; self-administration in elderly patients. PLGA coated RM-NPs prepared by solvent evaporation technique were incorporated into film prepared by solvent casting method. Optimized films with 1.127 g gellan gum and 1.962 % linoleic acid showed enhanced ex-vivo diffusion over a period of 72 h. Comparative pharmacokinetic study revealed increased bioavailability of rasagiline on transdermal application compared to oral route. In-vivo anti-Parkinson activity estimated by behavioural and biochemical analysis indicate reserpine to interfere with monoamine storage hence resulting in development of akinesia and PD-like symptoms in rats. Brain targeting monitored by gamma imaging showed effective brain drug uptake from transdermal film which was also supported by increased brain targeting efficiency estimated from biodistribution study. Thus, the data support efficacy of gellan gum film to target drug to brain region compared to oral route and hence can be employed as a convenient approach for long-term treatment of Parkinson's disease in elderly patients.

甲磺酸雷沙吉兰用作帕金森氏病早期治疗的一线药物，但其水溶性性质为跨血脑屏障创造了障碍，并且其口服生物利用度低且需要快速消除需要经常给药。因此，本研究旨在制备载有雷沙吉兰的甲磺酸雷沙吉兰纳米颗粒（RM-NPs）的吉兰糖胶透皮膜，用于非侵入性；老年患者的自我管理。将通过溶剂蒸发技术制备的PLGA涂覆的RM-NP掺入通过溶剂流延方法制备的膜中。使用1.127 g吉兰糖胶和1.962％亚油酸的优化薄膜在72小时内显示出增强的离体扩散。对比药代动力学研究表明，与口服途径相比，雷沙吉兰经皮施用具有更高的生物利用度。通过行为和生化分析估计的体内抗帕金森氏活性表明利血平会干扰单胺的储存，从而导致大鼠运动障碍和PD样症状的发展。通过伽马成像监测的脑靶向显示出了透皮薄膜对脑部药物的有效吸收，这也得到了生物分布研究估计的脑靶向效率的提高的支持。因此，与口服途径相比，吉兰糖胶膜将药物靶向脑区域的数据支持功效，因此可以用作长期治疗老年患者帕金森氏病的简便方法。