Classical characteristic of the innate immune system is the lack of ability to build up immunological memory, contrast to the adaptive immune system that is capable of “remembering” antigens, and rapidly mount a greater magnitude of immune response upon subsequent exposure to the same antigens. Peculiarly, immunological memory of innate immunity is evidenced in invertebrates. At least three different memory phenomena have been described, namely sustained unique response, recalled response, and immune shift. Studies attended to decipher the mechanistic biology of the innate immune memory reveals the role of epigenetics, which modulates the response of immune memory, and the heritability of immune memory to subsequent generations. A parthenogenetic Artemia model demonstrated successful transgenerational epigenetic inheritance of resistance trait against Vibrio campbellii. Following, the role of invertebrate hemocytes and Down syndrome cell adhesion molecule (Dscam) in innate immune memory is reviewed. While there is no vertebrate antibody homolog found in invertebrates, Dscam was found to resemble the functionality of vertebrate antibody. Insight of Dscam as immune factor was illustrated further in the current review.

先天性免疫系统的经典特征是缺乏建立免疫记忆的能力，这与能够“记忆”抗原的适应性免疫系统形成鲜明对比，并且在随后暴露于相同抗原后迅速产生更大的免疫反应。特别地，在无脊椎动物中证明了先天免疫的免疫学记忆。已经描述了至少三种不同的记忆现象，即持续的独特反应，回忆的反应和免疫转移。旨在破译先天免疫记忆机制生物学的研究揭示了表观遗传学的作用，后者调节免疫记忆的反应以及免疫记忆对后代的遗传性。孤雌生殖性贫血该模型证明了对坎贝尔弧菌的抗性性状的成功的跨世代表观遗传。接下来，综述了无脊椎动物血细胞和唐氏综合症细胞粘附分子（Dscam）在先天免疫记忆中的作用。尽管在无脊椎动物中未发现脊椎动物抗体同源物，但发现Dscam与脊椎动物抗体的功能相似。在本综述中进一步说明了Dscam作为免疫因子的洞察力。