Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.,Experimental Gerontology

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Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.
Experimental Gerontology ( IF 3.9 ) Pub Date : 2020-06-30 , DOI: 10.1016/j.exger.2020.111012
Iván Cuyul-Vásquez ₁ , Lily Berríos-Contreras ₂ , Stephanie Soto-Fuentes ₁ , Karina Hunter-Echeverría ₁ , Gabriel Nasri Marzuca-Nassr ₃

Affiliation

Background

Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis.

Aims

To determine the effects of RET on redox homeostasis in older people.

Study design

A systematic review and meta-analysis of randomized clinical trials identified by searching MEDLINE, Web of Science, EMBASE, Sportdiscus, LILACS, CENTRAL and CINAHL. We included studies of subjects aged 65 years or older, with or without pathologies, and including RET metrics with quantified molecular oxidation and antioxidant capacity outcomes.

Results

Fifteen studies were included in this review. Agreement between reviewers reached a kappa value of 0.725. There were a total of 614 participants, with an average age of 68.1 years. Five (for molecular oxidation markers) and three (for antioxidant capacity markers) studies included data that quantified the effects of RET on homeostasis redox. The results of the meta-analysis showed that there were no differences in the molecular oxidation markers (SMD = −0.26; 95% CI = −0.57 to 0.05; P = 0.10; I2 = 0%) and antioxidant capacity markers (SMD = 0.53; 95% CI = −0.20 to 1.26; P = 0.16; I2 = 71.5%) in healthy older people after a RET of 8–24 weeks compared to non-intervention.

Conclusions

Based on a small number of studies of low methodological quality, this systematic review with meta-analysis suggests that RET is not effective at reducing molecular oxidation markers in healthy older people. More research is needed on the effects of RET on redox homeostasis in older people.

PROSPERO registration number

CRD42019121529

中文翻译：

抵抗运动训练对老年人氧化还原稳态的影响。系统的审查和荟萃分析。

背景

实践证明，抵抗运动训练（RET）可有效降低老年人口患慢性病的风险，并且似乎可以调节氧化还原稳态。

目的

确定RET对老年人氧化还原稳态的影响。

学习规划

通过搜索MEDLINE，Web of Science，EMBASE，Sportdiscus，LILACS，CENTRAL和CINAHL确定的随机临床试验的系统评价和荟萃分析。我们纳入了研究对象，研究对象为65岁或65岁以上，有无病理学的受试者，并包括具有定量分子氧化和抗氧化能力结果的RET指标。

结果

该评价包括15项研究。审阅者之间的协议达成的kappa值为0.725。共有614名参与者，平均年龄为68.1岁。五项（针对分子氧化标记）和三项（针对抗氧化能力标记）研究包括量化RET对体内稳态氧化还原作用的数据。荟萃分析的结果表明，分子氧化标记（SMD = -0.26； 95％CI = -0.57至0.05；P = 0.10； I2 = 0％）和抗氧化剂容量标记（SMD = 0.53）没有差异。；在8-24周的RET后，与不进行干预相比，健康老年人中95％CI = −0.20至1.26；P = 0.16； I2 = 71.5％。