The lysosome is an essential catabolic organelle that consumes cellular biomass to regenerate basic building blocks that can fuel anabolic reactions. This simple view has evolved more recently to integrate novel functions of the lysosome as a key signaling center, which can steer the metabolic trajectory of cells in response to changes in nutrients, growth factors, and stress. Master protein kinases and transcription factors mediate the growth-promoting and catabolic activities of the lysosome and undergo a complex interplay that enables cellular adaptation to ever-changing metabolic conditions. Understanding how this coordination occurs will shed light on the fundamental logic of how the lysosome functions to control growth in the context of development, tissue homeostasis, and cancer.

溶酶体是必需的分解代谢细胞器，其消耗细胞生物质以再生可促进合成代谢反应的基本构件。最近，这种简单的观点得到了发展，将溶酶体的新功能整合为关键的信号传递中心，可以响应营养物，生长因子和压力的变化而引导细胞的代谢轨迹。主蛋白激酶和转录因子介导溶酶体的促生长和分解代谢活性，并经历复杂的相互作用，使细胞适应不断变化的代谢条件。了解这种协调作用是如何发生的，将阐明溶酶体在发育，组织稳态和癌症的背景下如何控制生长的基本逻辑。