Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years.,Neuroscience Bulletin

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Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years.
Neuroscience Bulletin ( IF 5.6 ) Pub Date : 2020-06-30 , DOI: 10.1007/s12264-020-00530-6
Hao Zhou ₁ , Xiu Xu ₂ , Weili Yan ₃ , Xiaobing Zou ₄ , Lijie Wu ₅ , Xuerong Luo ₆ , Tingyu Li ₇ , Yi Huang ₈ , Hongyan Guan ₉ , Xiang Chen ₁₀ , Meng Mao ₁₁ , Kun Xia ₁₂ , Lan Zhang ₁₁ , Erzhen Li ₉ , Xiaoling Ge ₁₃ , Lili Zhang ₁ , Chunpei Li ₁ , Xudong Zhang ₁₃ , Yuanfeng Zhou ₁ , Ding Ding ₁₄ , Andy Shih ₁₅ , Eric Fombonne ₁₆ , Yi Zheng ₁₇ , Jisheng Han ₁₈ , Zhongsheng Sun ₁₉ , Yong-Hui Jiang ₂₀ , Yi Wang ₁ ,

Affiliation

Department of Neurology, Children's Hospital of Fudan University, Shanghai, 201102, China.
Child Health Care, Children's Hospital of Fudan University, Shanghai, 201102, China.
Department of Clinical Epidemiology, Children's Hospital of Fudan University, Shanghai, 201102, China.
Child Development Behavior Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Department of Children and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, 150081, China.
Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Child Health Care, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, 610041, China.
Capital Institute of Pediatrics, Beijing, 100020, China.
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
Child Health Care, Chengdu Women and Children's Hospital, Chengdu, 610091, China.
Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410013, China.
Children's Hospital of Fudan University, Shanghai, 201102, China.
Huashan Hospital of Fudan University, Shanghai, 200040, China.
Autism Speaks, 1 East 33rd Street, New York, NY, 10016, USA.
Oregon Health and Science University, Portland, OR, 97239, USA.
Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Neuroscience Research Institute, Peking University, Beijing, 100191, China.
Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100021, China.
Department of Genetics and Pediatrics, Yale School of Medicine, New Haven, CT, 06520, USA.

This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder (ASD) in Chinese children. We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling. The Modified Chinese Autism Spectrum Rating Scale was used for the screening process. Of the target population of 142,086 children, 88.5% (n = 125,806) participated in the study. A total of 363 children were confirmed as having ASD. The observed ASD prevalence rate was 0.29% (95% CI: 0.26%–0.32%) for the overall population. After adjustment for response rates, the estimated number of ASD cases was 867 in the target population sample, thereby achieving an estimated prevalence of 0.70% (95% CI: 0.64%–0.74%). The prevalence was significantly higher in boys than in girls (0.95%; 95% CI: 0.87%–1.02% versus 0.30%; 95% CI: 0.26%–0.34%; P < 0.001). Of the 363 confirmed ASD cases, 43.3% were newly diagnosed, and most of those (90.4%) were attending regular schools, and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity. Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children.

更新日期：2020-06-30

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