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Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy
Nano-Micro Letters ( IF 31.6 ) Pub Date : 2020-06-30 , DOI: 10.1007/s40820-020-00465-7
Xin Peng 1 , Kun Chen 2 , Wanhua Liu 1 , Xiongfeng Cao 3 , Mengru Wang 1 , Jun Tao 2 , Ying Tian 4 , Lei Bao 5 , Guangming Lu 4 , Zhaogang Teng 2, 4
Affiliation  

  • Soft mesoporous organosilica nanoplatforms modified with hyaluronic acid and cyanine 5.5 are constructed.

  • Therapeutic efficacy of the soft nanoplatforms on tumor is higher both in vitro and in vivo after loading photosensitizer chlorin e6 compared to that of stiff counterparts.



中文翻译:

柔软的中孔有机硅纳米平台可改善血液循环,肿瘤积累/渗透和光动力功效

  • 构造了用透明质酸和花菁5.5改性的软介孔有机二氧化硅纳米平台。

  • 装载光敏剂二氢卟酚e6后,软纳米平台对肿瘤的治疗功效在体外和体内均高于刚性对等药物。

更新日期:2020-06-30
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