Abstract

Baicalin (BC)-rare earth metal complexes [BMCs (BC-Ce, BC-La, and BC-Y)] were synthesized by a complexation coordination method. A mouse tumor model with SMMC-7721 cells was used to examine BMCs for their anti-tumor activities in vivo. The results show that the three new BMCs, Na₃Ce (C₂₁H₁₆O₁₁)₃·10H₂O, Na₂La (C₂₁H₁₆O₁₁)₂·8H₂O, and Na₂Y (C₂₁H₁₆O₁₁)₂·6H₂O significantly inhibited SMMC-7721 cell proliferation, since the BMCs may induce the tumor apoptosis in a dose-dependent manner through decreasing cell membrane fluidity and mitochondrial membrane potential depolarization, blocking of the cell cycle at the G₂/M phase, and increasing the expression of Bax and reducing the expression of Bcl-2. The effectiveness order of these three BCMs was as follows: BC-Ce > BC-La > BC-Y > BC. It is concluded that BC-Ce, BC-La, and BC-Y possess potent anti-tumor effects and may be a novel group of anti-tumor drugs.

Graphic abstract

The novel baicalin-rare earth metal complexes (BMC) were synthesized, the anti-tumor effects of the BMC on SMMC-7721 cell analyzed comprehensively.

中文翻译：

---

合成的黄ical素稀土金属配合物对SMMC-7721细胞的抗肿瘤作用。

摘要

通过络合配位方法合成了黄ical苷（BC）-稀土金属络合物[BMC（BC-Ce，BC-La和BC-Y）]。具有SMMC-7721细胞的小鼠肿瘤模型用于检查BMC在体内的抗肿瘤活性。结果表明，三种新的BMC分别为Na ₃ Ce（C ₂₁ H ₁₆ O ₁₁）₃ ·10H ₂ O，Na ₂ La（C ₂₁ H ₁₆ O ₁₁）₂ ·8H ₂ O和Na ₂ Y（C _21）。 H ₁₆ O ₁₁）₂ ·6H ₂O显着抑制SMMC-7721细胞增殖，因为BMC可以通过降低细胞膜流动性和线粒体膜电位去极化，阻断G ₂ / M期的细胞周期并增加细胞周期以剂量依赖的方式诱导肿瘤凋亡。的表达Bax的和减少的表达的Bcl - 2。这三个BCM的有效性顺序如下：BC-Ce> BC-La> BC-Y> BC。结论是BC-Ce，BC-La和BC-Y具有有效的抗肿瘤作用，可能是一类新型的抗肿瘤药物。

图形摘要

合成了新型黄ical素-稀土金属配合物（BMC），全面分析了BMC对SMMC-7721细胞的抗肿瘤作用。