This work is focused on the characterization by transmission and scanning–transmission electron microscopy-related techniques of core–shell nanoparticles synthesized via chemical methods. Different semiconducting, pure metallic or oxide materials have been utilized as the core (cadmium telluride, gold, magnetite, or magnetite covered with gold) of the nanoparticle, while they have been, in all cases, functionalized by a thin amorphous glutathione layer, with the goal of using the nanoparticles in biomedical applications such as biomarkers, and computerized tomography and image magnetic resonance contrast agents. The results show that it is possible to visualize the glutathione layer using spectroscopic and imaging techniques, associated with electron microscopy (such as energy-dispersive X-ray spectroscopy and high-resolution transmission electron microscopy images), that this layer is present at the surfaces of all observed nanoparticles, and that it is no thicker than a few nanometers. Electron microscopy also revealed that the nanoparticles core is crystalline and, in average, around 5-nm size.

中文翻译：

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化学合成谷胱甘肽去壳纳米粒子的（S）TEM结构和组成纳米分析

这项工作的重点是通过透射和扫描-透射电子显微镜相关技术对通过化学方法合成的核壳纳米粒子进行表征。不同的半导体，纯金属或氧化物材料已被用作纳米粒子的核心（碲化镉，金，磁铁矿或被金覆盖的磁铁矿），而在所有情况下，它们均已被无定形的谷胱甘肽薄层功能化，目标是在生物医学应用（例如生物标记物）以及计算机断层扫描和图像磁共振造影剂中使用纳米颗粒。结果表明，使用光谱和成像技术可以可视化谷胱甘肽层，与电子显微镜（例如能量色散X射线光谱和高分辨率透射电子显微镜图像）相关联，该层存在于所有观察到的纳米粒子的表面，并且其厚度不超过几纳米。电子显微镜还显示，纳米颗粒核是结晶的，平均大小约为5 nm。