Two novel α, β-unsaturated bis-enone derivatives (1 and 2) were designed, synthesized and characterized by infrared radiation (IR), 1H nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS), and single crystal X-ray crystallography. The anticancer activity of the two compounds were investigated against four human gastric cancer cells (MGC-803, SGC-790, MKN45 and AGS) by (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Furthermore, molecular docking study supported the biological assay data and suggested that compound 1 may be a potential anticancer agent.

中文翻译：

---

两种新的α，β-不饱和双烯酮衍生物：抗胃癌活性和对接研究

设计，合成和表征了两种新颖的α，β-不饱和双烯酮衍生物（1和2），并通过红外辐射（IR），1H核磁共振（NMR），高分辨率质谱（HRMS）和单晶X进行了表征射线晶体学。通过（3-（4,5-Dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide）研究了这两种化合物对四种人胃癌细胞（MGC-803，SGC-790，MKN45和AGS）的抗癌活性。 （MTT）分析此外，分子对接研究支持生物学分析数据，并表明化合物1可能是潜在的抗癌药。