Two new Cu(II)-based coordination polymers with the chemical formulae of [Cu3(TCA)2(pz)2]·DMF·6H2O (1, pz = pyrazine) and [Cu3(TCA)(4,4-bpy)1.5(OH)3] 3DEF (2, bpy = 4,4-bipyridine, DEF = N,N-diethylformamide) have been successfully prepared by the reaction of a tritopic carboxylic acid 4,4’,4”-nitrilotribenzoic acid (H3TCA) ligand with Cu(NO3)2·3H2O in the presence of different N-donor co-ligands under the solvothermal conditions. The structures of the two as-prepared complexes have been unambiguously determined by single-crystal X-ray study. Furthermore, the anti-proliferation ability of the compounds 1 and 2 on H9C2 myocardial aneurysm cells was evaluated by CCK-8 assay and the colony formation assay. Besides, the migration and invasion capability of H9C2 cells after treated with synthesized complexes was detected by transwell assay.

中文翻译：

---

两种铜（II）配位聚合物对人心肌动脉瘤细胞的结构多样性和抗癌活性

两种新的化学式为[Cu3（TCA）2（pz）2]·DMF·6H2O（1，pz =吡嗪）和[Cu3（TCA）（4,4-bpy）的基于Cu（II）的配位聚合物1.5（OH）3] 3DEF（2，bpy = 4,4-联吡啶，DEF = N，N-二乙基甲酰胺）已通过三主题羧酸4,4'，4”-亚硝基三苯甲酸（H3TCA）的反应成功制备在溶剂热条件下，在不同的N-供体共配体存在下，用Cu（NO3）2·3H2O配体。两种制备的配合物的结构已通过单晶X射线研究明确确定。此外，通过CCK-8测定和集落形成测定来评价化合物1和2对H9C2心肌动脉瘤细胞的抗增殖能力。此外，通过transwell法检测了合成的复合物处理后H9C2细胞的迁移和侵袭能力。