To understand the magnesium (Mg) degradation mechanism in vivo, a variety of in vitro investigations have been conducted. However, there is still a gap between in vitro results and in vivo observations. Herein, the combined effect of proteins and medium-flow conditions on magnesium degradation was studied. Bovine serum albumin (BSA) and fetal bovine serum (FBS) were employed as the commonly used protein components for in vitro tests. Static, medium-changing (semi-static) and continuous-medium-flow (dynamic) conditions were used as different conditions. The results showed the highest inhibition efficiency of BSA and FBS on magnesium degradation under static conditions, while the efficiency largely decreased under semi-static or dynamic conditions, particularly for BSA. The possible explanations are related to the composition of degradation products and the integrity of the degradation layer. These results emphasize the importance of considering effects from different factors during magnesium degradation.

中文翻译：

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蛋白质和中等流动条件：它们如何影响镁的降解

为了了解体内镁（Mg）的降解机理，已进行了各种体外研究。但是，体外结果与体内观察结果之间仍然存在差距。在此，研究了蛋白质和中等流动条件对镁降解的综合影响。牛血清白蛋白（BSA）和胎牛血清（FBS）被用作体外测试中常用的蛋白质成分。静态，中等变化（半静态）和连续中等流量（动态）条件用作不同条件。结果表明，BSA和FBS在静态条件下对镁降解的抑制效率最高，而在半静态或动态条件下效率则大大降低，尤其是BSA。可能的解释与降解产物的组成和降解层的完整性有关。这些结果强调了在镁降解过程中考虑不同因素影响的重要性。