Poly(vinyl alcohol) (PVA) hydrogels become muddy while used in artificial corneas. To enhance the antifouling property of PVA hydrogels, a PVA hydrogel was grafted with chondroitin sulfate (CdS) through a two-step reaction in this work. The surface chemical compositions, surface morphology and thermal property of the hydrogel were characterized by attenuated total reflectance FTIR, X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy and thermogravimetric analysis. It was confirmed that CdS was successfully grafted onto the surface of the PVA hydrogel through a two-step method. After grafting with p(GMA-CdS) (GMA: glycidyl methacrylate), both the thermal and mechanical properties of the PVA hydrogel became weaker and the PVA hydrogel became hydrophilic. The biocompatibility of the PVA-g-p(GMA-CdS) hydrogel could be considered as non-cytotoxic according to ISO 10993-5:2009. The antifouling property of the PVA-g-p(GMA-CdS) hydrogel, namely its anti-protein adsorption and anti-cell adhesion, was significantly improved due to surface hydration, steric exclusion effect and charge surface. The anti-protein adsorption of the PVA-g-p(GMA-CdS) hydrogel increased by about 33·48% in comparison with that of the PVA hydrogel and the anti-cell adhesion increased by about 67·92%. Overall, the PVA-g-p(GMA-CdS) hydrogel is an ideal biomaterial candidate for artificial corneas.

中文翻译：

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在聚乙烯醇上用硫酸软骨素接枝以提高防污性能

聚乙烯醇（PVA）水凝胶在人造角膜中使用时变得浑浊。为了增强PVA水凝胶的防污性能，在这项工作中，通过两步反应将硫酸软骨素（CdS）接枝了PVA水凝胶。通过衰减全反射FTIR，X射线光电子能谱，原子力显微镜，扫描电子显微镜和热重分析来表征水凝胶的表面化学组成，表面形态和热性能。证实了通过两步法将CdS成功地接枝到PVA水凝胶的表面上。用p（GMA-CdS）（GMA：甲基丙烯酸缩水甘油酯）接枝后，PVA水凝胶的热和机械性能均变弱，PVA水凝胶变得亲水。PVA- g的生物相容性-p（GMA-CdS）水凝胶可根据ISO 10993-5：2009视为无细胞毒性。PVA - g -p（GMA-CdS）水凝胶的防污性能，即其抗蛋白质吸附和抗细胞粘附性，由于表面水合作用，空间排阻作用和电荷表面而得到显着改善。与PVA水凝胶相比，PVA- g -p（GMA-CdS）水凝胶的抗蛋白质吸附增加了约33·48％，抗细胞粘附增加了约67·92％。总体而言，PVA - g -p（GMA-CdS）水凝胶是人造角膜的理想生物材料候选物。