Background: Calcium carbonate (CC) nanoparticles have broad biomedical utilizations, owing to their multiple intrinsic merits. However, bare CC nanoparticles do not allow for the development of multifunctional devices suitable for advanced drug delivery in cancer therapy.
Methods: Phospholipid-modified phospholipid–CC hybrid nanoparticles were prepared in our study using a combination of vapor-diffusion and solvent-diffusion methods to offer optimized pharmaceutical capabilities.
Results: Considering that particle size is a critical parameter that plays an important role in both in vitro and in vivo behaviors of nanoparticles, we here for the first time a present detailed protocol for the size-controlled preparation of hybrid nanoparticles, as well as analysis of the in vitro/in vivo behaviors of differently sized hybrid nanoparticles.
Conclusion: Our results might significantly advance the application of this promising material in more varied fields.



中文翻译：

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磷脂-碳酸钙杂化纳米粒子的尺寸控制制备和行为研究。

背景：碳酸钙（CC）纳米颗粒具有广泛的生物医学用途，因为它们具有多种内在优点。然而，裸 CC 纳米粒子不允许开发适用于癌症治疗中先进药物递送的多功能设备。
方法：在我们的研究中，使用气相扩散和溶剂扩散方法的组合制备了磷脂修饰的磷脂-CC 杂化纳米颗粒，以提供优化的制药能力。
结果：考虑到粒径是一个关键参数，在纳米粒子的体外和体内行为中都起着重要作用，我们在这里首次提出了混合纳米粒子的尺寸控制制备的详细方案，以及分析不同大小的杂化纳米粒子的体外/体内行为。
结论：我们的结果可能会显着推动这种有前途的材料在更多领域的应用。