A broad range of polymers have been utilized for the development of blood-contacting implantable medical devices; however, their rate of failure has raised the need for developing more hemocompatible biomaterial surfaces. In this study, a novel scaffold based on polycaprolactone incorporated with 10% and 15% (w/w) Tulbaghia violacea plant extracts were fabricated using electrospinning technique. The fabricated scaffolds were then treated with T. violacea aqueous plant extracts (100 and 1000 µg/mL) to investigate their use as interfaces for blood-contacting implants. The 10% Tvio scaffold produced the lowest mean fibre diameter (193 ± 30 nm), whereas the 15% Tvio scaffold produces the highest mean fibre diameter (538 ± 236 nm) when compared with the control polycaprolactone (275 ± 61 nm) scaffold. The number of adhered platelets was directly linked to fibre diameter and concentration of plant extract in such a way that the lowest fibre diameter scaffold (10% Tvio) inhibited platelet adhesion, whereas more platelets adhered to the scaffold with the highest fibre diameter (15% Tvio scaffolds). There was also an increase in platelet adhesion as the concentration of T. violacea was increased from 100 to 1000 µg/mL for all designed scaffolds. The improved blood compatibility demonstrated by the 10% Tvio scaffold suggests that the plant possesses antithrombogenic properties, particularly at lower concentrations.

中文翻译：

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Tulbaghia violacea负载的聚己内酯纳米纤维的抗血栓形成特性

广泛的聚合物已被用于开发接触血液的植入式医疗器械；然而，它们的失败率提高了开发血液相容性更好的生物材料表面的必要性。在这项研究中，使用静电纺丝技术制造了一种基于聚己内酯的新型支架，其中掺入了 10% 和 15% (w/w) 紫罗兰植物提取物。然后用紫罗兰植物水提取物（100 和 1000 µg/mL）处理制造的支架，以研究它们作为血液接触植入物的界面的用途。与对照聚己内酯 (275 ± 61 nm) 支架相比，10% Tvio 支架产生的平均纤维直径最低 (193 ± 30 nm)，而 15% Tvio 支架产生的平均纤维直径最高 (538 ± 236 nm)。粘附血小板的数量与纤维直径和植物提取物的浓度直接相关，因此纤维直径最低的支架（10% Tvio）抑制血小板粘附，而更多的血小板粘附在纤维直径最高的支架上（15% Tvio 脚手架）。对于所有设计的支架，随着紫锥虫的浓度从 100 µg/mL 增加到 1000 µg/mL，血小板粘附也有所增加。10% Tvio 支架所证明的改善的血液相容性表明该植物具有抗血栓形成特性，尤其是在较低浓度下。而更多的血小板粘附在纤维直径最高的支架上（15% Tvio 支架）。对于所有设计的支架，随着紫锥虫的浓度从 100 µg/mL 增加到 1000 µg/mL，血小板粘附也有所增加。10% Tvio 支架所证明的改善的血液相容性表明该植物具有抗血栓形成特性，尤其是在较低浓度下。而更多的血小板粘附在纤维直径最高的支架上（15% Tvio 支架）。对于所有设计的支架，随着紫锥虫的浓度从 100 µg/mL 增加到 1000 µg/mL，血小板粘附也有所增加。10% Tvio 支架所证明的改善的血液相容性表明该植物具有抗血栓形成特性，尤其是在较低浓度下。