Letter to Editor Re: Fang et al entitled "Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China".,Dose-Response

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Letter to Editor Re: Fang et al entitled "Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China".
Dose-Response ( IF 2.3 ) Pub Date : 2020-06-10 , DOI: 10.1177/1559325820922101
Kanokporn Noy Rithidech ₁ , S M J Mortazavi ₂ , Antone L Brooks ₃

Affiliation

With great concern, we read an article by Fang et al entitled “Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China” recently published in the journal Dose-Response.¹ This is an important issue associated with radiation protection since the accurate assessment of health risks from such low-dose radiation remains challenging and controversial. However, the presentation and conclusion of this work are ambiguous. We focus our comments on the foremost limitation of the article by Fang et al¹ (ie, the analyses of cytogenetic data) that weakens their conclusion of a strong correlation between genomic instability and the duration of exposure to low-dose radiation. The use of working years to categorize the subjects is inappropriate and should not be used since there were large variations in exposure levels in each group of workers. A more accurate metric to relate biological damage to exposure is the level of radiation dose.

更新日期：2020-06-30

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