Equilibrium constants and reaction rate constants for the esterification of secondary alkan-2-ols with acetic acid were measured at 60°C in 1,4-dioxane. Taft coefficients, as single parameter (without inductive effects), and two-parameter correlation (including inductive and steric effects), of the measurements were used for the prediction of esterification rate constants for secondary alkan-2-ols with monocarboxylic acids. For this prediction, previously observed results of linear correlation of rate constants for the esterification of propan-1-ol with monocarboxylic acids measured under identical experimental conditions were applied. Two parameter Taft equations for the correlation of secondary alkan-2-ols and for monocarboxylic acids were combined, resulting in an overall correlation equation usable for the prediction of reaction rates for secondary alkan-2-ols with any monocarboxylic acid. This equation was experimentally verified for the esterification of three randomly chosen alkan-2-ols with three randomly chosen monocarboxylic acids.

中文翻译：

---

基于单参数和双参数 Taft 方程预测仲链烷-2-醇的酯化速率常数

在 60°C 下在 1,4-二恶烷中测量仲链烷-2-醇与乙酸酯化的平衡常数和反应速率常数。塔夫脱系数作为单个参数（无感应效应）和双参数相关性（包括感应和空间效应），用于预测具有一元羧酸的仲链烷-2-醇的酯化速率常数。对于该预测，应用先前观察到的在相同实验条件下测量的 1-丙醇与一元羧酸酯化的速率常数的线性相关性结果。将用于仲链烷-2-醇和一元羧酸的相关性的两个参数 Taft 方程结合起来，产生了一个整体相关方程，可用于预测仲链烷-2-醇与任何单羧酸的反应速率。该方程在三个随机选择的 2-链烷醇与三个随机选择的单羧酸的酯化中得到了实验验证。