3D bioprinting may revolutionize the field of tissue engineering by allowing fabrication of bio-structures with a high degree of complexity, fine architecture and heterogeneous composition. The printing substances in these processes are mostly based on biomaterials and living cells. As such, they generally possess weak mechanical properties and thus must be supported during fabrication in order to prevent the collapse of large, volumetric multi-layered printouts. In this work, we characterize a uniquely formulated media used to support printing of extracellular matrix-based biomaterials. We show that a hybrid material, comprised of calcium-alginate nanoparticles and xanthan gum, presents superb qualities that enable printing at high resolution of down to 10 microns, allowing fabrication of complex constructs and cellular structures. This hybrid also presents an exclusive combination of desirable properties such as biocompatibility, high transparency, stability at a wide range of...

中文翻译：

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用于高分辨率 3D 打印体积单元的 ECM 结构的透明支撑介质。

通过允许制造具有高度复杂性、精细结构和异质成分的生物结构，3D 生物打印可能会彻底改变组织工程领域。这些过程中的打印物质大多以生物材料和活细胞为基础。因此，它们通常具有较弱的机械性能，因此必须在制造过程中得到支撑，以防止大体积的多层打印输出坍塌。在这项工作中，我们表征了一种独特配方的介质，用于支持基于细胞外基质的生物材料的打印。我们展示了一种由海藻酸钙纳米颗粒和黄原胶组成的混合材料，具有卓越的品质，能够以低至 10 微米的高分辨率进行打印，从而可以制造复杂的结构和细胞结构。