In this study, hydrophilic pullulan, which is favorable for cell adhesion, proliferation, and differentiation, was selected as a modifier for the preparation of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB))/pullulan nanofibers via electrospinning to improve the biocompatibility of P(3HB-co-4HB) and increase the drug loading of composite fibers. Alkyl polyglycoside was used as the emulsifying agent to promote emulsification and stabilize the P(3HB-co-4HB)/pullulan composite solution. Drug-loading property of the nanofibers with a shell-core structure is increased because gelatin was not formed into fibers via electrospinning, thereby forming a stable drug-containing gelatin solution in the core layer. Finally, P(3HB-co-4HB)/pullulan-gelatin shell-core nanofibers were prepared. The intermolecular interaction, morphology, crystallization properties, mechanical properties, morphology, sustained release, and biocompatibility of composite nanofibers were characterized. ...

中文翻译：

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具有壳核结构的聚（3-羟基丁酸酯-co-4-羟基丁酸酯）/普鲁兰多糖-明胶电纺纳米纤维的制备和表征。

本研究选用有利于细胞粘附、增殖和分化的亲水性支链淀粉作为改性剂制备聚(3-羟基丁酸-co-4-羟基丁酸)(P(3HB-co-4HB)) /普鲁兰多糖纳米纤维通过静电纺丝提高P(3HB-co-4HB)的生物相容性并增加复合纤维的载药量。以烷基多糖苷为乳化剂，促进乳化，稳定P(3HB-co-4HB)/普鲁兰多糖复合溶液。由于明胶没有通过静电纺丝形成纤维，因此具有壳核结构的纳米纤维的载药性能增加，从而在核层中形成稳定的含药明胶溶液。最后，制备了P(3HB-co-4HB)/普鲁兰多糖-明胶壳核纳米纤维。分子间相互作用、形态、表征了复合纳米纤维的结晶性能、机械性能、形态、缓释和生物相容性。...