Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging.,Journal of Materials Chemistry B

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Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-06-29 , DOI: 10.1039/d0tb00173b
Hengyan Liu ₁ , Ge Xu , Tianli Zhu , Rongchen Wang , Jiahui Tan , Chunchang Zhao , Xianfeng Gu

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We present an approach for constructing a H₂S-specific nanoprobe by the entrapment of a small molecule probe within the hydrophobic interior of surface cross-linked micelles (SCMs), endowing the designed nanoprobes with good water solubility and biocompatibility. Importantly, the obtained nanoprobes displayed good responsiveness to H₂S in both ratiometric fluorescence and light-up NIR emission modes, thus enabling accurate identification of H₂S-rich colorectal cancer cells.

中文翻译：

具有H2S触发的NIR发射的水分散性和生物相容性纳米探针的合理设计，用于癌细胞成像。

我们提出了一种通过在表面交联的胶束（SCMs）的疏水内部包裹小分子探针来构建H ₂ S特异性纳米探针的方法，赋予设计的纳米探针良好的水溶性和生物相容性。重要的是，所获得的纳米探针在比例荧光和点亮NIR发射模式下均显示出对H ₂ S的良好响应性，从而能够准确鉴定富含H ₂ S的结直肠癌细胞。

更新日期：2020-07-22

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