Background: Alterations in airway smooth muscle cells cause an increase in their mass and result in a significant impact on airway remodeling diseases such as asthma and chronic obstructive pulmonary disease. Several studies have used platelet-derived growth factors to stimulate the alterations of airway smooth muscle cells.

Objective: This review discusses the platelet-derived growth factor-stimulated alterations of airway smooth muscle cells, diversity of inhibitors and inhibitory actions against these alterations and their related mechanisms, and how this diversity presents an avenue for the development of multifarious therapeutic targets for airway remodeling diseases especially asthma and chronic obstructive pulmonary disease.

Methods: A comprehensive search of PubMed and Medscape database for studies that investigated the stimulation of the alterations of airway smooth muscle cells in asthma and chronic obstructive pulmonary disease by platelet-derived growth factors and inhibitions of these alterations.

Results: Marked platelet-derived growth factor-stimulated alterations of airway smooth muscle cells are proliferation, migration and proliferative phenotype with diverse inhibitors and inhibitory actions against these alterations. Inhibitory actions are the result of the activation of protein kinase, overexpression of Tripartite motif protein, human transporter sub-family ABCA1 protein and miRNAs, knockdown of an isoform of reticulon 4 and follistatin protein, exogenous applications of recombinant proteins, supplements and active metabolite of retinoic acid, flavonoid extracts and polysaccharides extract.

Conclusion: The multifarious inhibitors and inhibitory actions with varied mechanisms in platelet-derived growth factors-stimulated alterations of airway smooth muscle cells present a potential for diverse therapeutic targets for the treatment of airway remodeling diseases.

背景：气道平滑肌细胞的改变会导致其质量增加，并对气道重塑疾病（例如哮喘和慢性阻塞性肺疾病）产生重大影响。一些研究已经使用血小板衍生的生长因子来刺激气道平滑肌细胞的改变。

目的：本综述讨论了血小板衍生的生长因子刺激的气道平滑肌细胞改变，抑制剂的多样性以及针对这些改变的抑制作用及其相关机制，以及这种多样性如何为开发多种气道治疗靶标提供了途径重塑疾病，尤其是哮喘和慢性阻塞性肺疾病。

方法：全面搜索PubMed和Medscape数据库，以研究血小板衍生的生长因子对哮喘和慢性阻塞性肺疾病气道平滑肌细胞变化的刺激作用以及对这些变化的抑制作用。

结果：标记的血小板衍生的生长因子刺激的气道平滑肌细胞改变是具有多种抑制剂的增殖，迁移和增殖表型，以及对这些改变的抑制作用。抑制作用是蛋白激酶激活，三方基序蛋白过表达，人转运蛋白亚家族ABCA1蛋白和miRNA的表达，网状蛋白4和卵泡抑素蛋白同工型的敲除，重组蛋白的外源应用，维生素A的补充剂和活性代谢产物的结果视黄酸，类黄酮提取物和多糖提取物。

结论：血小板源性生长因子刺激的气道平滑肌细胞变化的多种抑制剂和不同机制的抑制作用为治疗气道重塑疾病提供了多种治疗靶标的潜力。