Trillions of microorganisms reside in the hosts' gut. Since diverse activities of gut microbiota affect the hosts' health status, maintenance of gut microbiota is important for maintaining human health. Green tea (GT) has multiple beneficial effects on energy metabolism with antiobesity, antidiabetic, and hypolipidemic properties. As GT contains a large amount of bioactive ingredients (e.g., catechins), which can be metabolized by microorganisms, it would be feasible that consumption of GT may cause compositional changes in gut microbiota, and that the changes in gut microbiota would be associated with the beneficial effects of GT. In this study, we demonstrated that consumption of GT extract relieves high-fat diet-induced metabolic abnormalities. Interestingly, GT administration significantly encouraged the growth of Akkermansia muciniphila (Akkermansia), a beneficial microorganism to relieve obesity and related metabolic disorders. Finally, we found that epigallocatechin gallate is the component of GT that stimulates the growth of Akkermansia. According to these data, we propose that GT could be a prebiotic agent for Akkermansia to treat metabolic syndromes.

中文翻译：

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绿茶鼓励阿克曼草（Akkermansia muciniphila）的生长。

一小撮微生物驻留在宿主的肠道中。由于肠道菌群的各种活动影响宿主的健康状况，因此维持肠道菌群对于维持人类健康很重要。绿茶（GT）具有抗肥胖，抗糖尿病和降血脂特性，对能量代谢具有多种有益作用。由于GT含有大量生物活性成分（例如（儿茶素类，儿茶素类），可以被微生物代谢，食用GT可能会引起肠道菌群组成的改变，并且肠道菌群的改变与GT的有益作用有关是可行的。在这项研究中，我们证明了食用GT提取物可以缓解高脂饮食引起的代谢异常。有趣的是，GT的使用极大地促进了黏液Akkermansia muciniphila（Akkermansia）的生长，这是一种有益于减轻肥胖症和相关代谢异常的微生物。最后，我们发现表没食子儿茶素没食子酸酯是刺激阿克曼病生长的GT的组成部分。根据这些数据，我们建议GT可能是Akkermansia的益生元 治疗代谢综合症。