The mechanisms of genetic alteration are checked to be responsible for the oral cancer incidence. Herein, this meta-analysis aimed to assess the association between -1082A/G, -592A/C, and -819T/C polymorphisms of interleukin (IL)-10 and susceptibility to oral cancer. We systematically searched the PubMed, Web of Science, Cochrane Library, and Scopus databases until May 2019 to find the studies reporting the association between the IL-10 polymorphisms and the oral cancer risk. Rev Man 5.3 software was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). The CMA (version 2.0) software showed the results of publication bias. In addition, SPSS (version 22.0) was used for meta-regression analysis. Out of 8 studies included in this meta-analysis, 7, 6, and 5 studies reported -1082A/G, -592A/C, and -819T/C polymorphisms, respectively. The pooled ORs of the allele, homozygote, heterozygote, dominant, and recessive models were 1.64 (95% CI: 1.26–2.13), 2.99 (95% CI: 1.32–6.79), 1.64 (95% CI: 1.16–2.33), 1.77 (95% CI: 1.25–2.49), and 2.44 (95% CI: 1.21–4.92), respectively, showing a significant association for -1082A/G polymorphism, but not for -592A/C, and -819T/C polymorphisms with the risk of oral cancer. However, subgroup analysis showed an association for -592A/C polymorphisms, Caucasian ethnicity, and hospital-based controls. In summary, the findings of this meta-analysis illustrated an elevated risk of oral cancer related to -1082A/G polymorphism, but there was no association between -592A/C and -819C/T polymorphisms and the risk of oral cancer.

中文翻译：

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口腔癌中白细胞介素10（-1082A / G，-592A / C和-819C / T）的常见多态性：最新的荟萃分析。

检查遗传改变的机制是导致口腔癌发生的原因。本文中，这项荟萃分析旨在评估白介素（IL）-10的-1082A / G，-592A / C和-819T / C多态性之间的关联以及对口腔癌的敏感性。我们系统搜索了PubMed，Web of Science，Cochrane图书馆和Scopus数据库，直到2019年5月才找到报告IL-10多态性与口腔癌风险之间相关性的研究。使用Rev Man 5.3软件计算比值比（OR）和95％置信区间（CIs）。CMA（2.0版）软件显示了发布偏差的结果。此外，SPSS（版本22.0）用于元回归分析。在该荟萃分析中的8项研究中，有7项，6项和5项研究分别报告了-1082A / G，-592A / C和-819T / C多态性。等位基因，纯合子，杂合子，显性和隐性模型的合并OR分别为1.64（95％CI：1.26-2.13），2.99（95％CI：1.32-6.79），1.64（95％CI：1.16-2.33）， 1.77（95％CI：1.25–2.49）和2.44（95％CI：1.21–4.92），分别显示了-1082A / G多态性与-592A / C和-819T / C多态性与口腔癌风险的显着相关性。但是，亚组分析显示-592A / C多态性，白种人与医院控制相关。总而言之，这项荟萃分析的结果表明与-1082A / G多态性相关的口腔癌风险升高，但-592A / C和-819C / T多态性与口腔癌的风险之间没有关联。