We report the synthesis and antimicrobial studies of a new series of naphthyl-substituted pyrazole-derived hydrazones. Many of these novel compounds are potent growth inhibitors of several strains of drug-resistant bacteria. These potent compounds have inclined growth inhibitory properties for planktonic Staphylococcus aureus and Acinetobacter baumannii, and its drug-resistant variants with minimum inhibitory concentration (MIC) as low as 0.78 and 1.56 µg ml⁻¹, respectively. These compounds also show potent activity against S. aureus and A. baumannii biofilm formation and eradication properties. Time Kill Assay shows that these compounds are bactericidal for S. aureus and bacteriostatic for A. baumannii. The probable mode of action is the disruption of the bacterial cell membrane. Furthermore, potent compounds are nontoxic to human cell lines at several fold higher concentrations than the MICs.

我们报告了一系列新的萘基取代吡唑衍生的的合成和抗菌研究。这些新化合物中的许多是几种耐药细菌菌株的有效生长抑制剂。这些有效的化合物对浮游性金黄色葡萄球菌和鲍曼不动杆菌及其倾斜最小抑菌浓度（MIC）分别为0.78和1.56 µg ml ^-1的耐药变异体具有倾斜的生长抑制特性。这些化合物还显示出对金黄色葡萄球菌和鲍曼不动杆菌生物膜形成和根除特性的有效活性。时间杀伤试验表明这些化合物对金黄色葡萄球菌具有杀菌作用对鲍曼不动杆菌具有抑菌作用。可能的作用方式是破坏细菌细胞膜。此外，强效化合物对人细胞系无毒，浓度比MIC高几倍。