The mechanism underlying glomerular filtration barrier selectivity has not been resolved. A new study that reports an inverse correlation between slit diaphragm density and proteinuria in a genetic mouse model of focal segmental glomerulosclerosis suggests that podocytes function to compress the glomerular basement membrane (GBM) and that failure of this process results in GBM stretching and increased permeability.

中文翻译：

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在了解肾小球滤过性方面迈出了一步。

肾小球滤过屏障选择性的潜在机制尚未解决。一项新的研究报道了在局灶性节段性肾小球硬化的遗传小鼠模型中缝隙隔膜密度与蛋白尿之间的负相关关系表明，足细胞起着压缩肾小球基底膜（GBM）的作用，并且该过程的失败导致GBM的拉伸和通透性的增加。