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NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-06-29 , DOI: 10.1021/acsami.0c07503 Feiyang Jin 1 , Jing Qi 1 , Minxia Zhu 1 , Di Liu 1 , Yuchan You 1 , Gaofeng Shu 2 , Yan Du 1 , Jun Wang 1 , Hui Yu 1 , Mingchen Sun 1 , Xiaoling Xu 1 , Qiying Shen 1 , Xiaoying Ying 1 , Jiansong Ji 2 , Yongzhong Du 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-06-29 , DOI: 10.1021/acsami.0c07503 Feiyang Jin 1 , Jing Qi 1 , Minxia Zhu 1 , Di Liu 1 , Yuchan You 1 , Gaofeng Shu 2 , Yan Du 1 , Jun Wang 1 , Hui Yu 1 , Mingchen Sun 1 , Xiaoling Xu 1 , Qiying Shen 1 , Xiaoying Ying 1 , Jiansong Ji 2 , Yongzhong Du 1
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A desirable cancer therapeutic strategy is supposed to have effective ability to not only exert maximum anticancer ability but also inspire antitumor immunity for preventing tumor relapse and metastasis. During this research, multifunctional upconversion nanoparticles (UCNPs) coated by ROS-responsive micelles are prepared for tumor targeting and near-infrared (NIR)-triggered photodynamic therapy (PDT)-combined synergistic effect of chemotherapy. Moreover, both PDT and chemotherapy agents could activate antitumor immunity via inducing immunogenic cell death with CD8+ and CD4+ T cells infiltrating in tumors. Through the experiments, intravenous administration of multifunctional nanocarriers with noninvasive NIR irradiation destroys the orthotopic tumors and efficiently suppresses lung metastasis in a metastatic triple-negative breast cancer model by cascade-amplifying chemo-PDT and systemic antitumor immunity. In conclusion, this study provides prospective chemo-PDT with inspired antitumor immunity for metastatic cancer treatment.
中文翻译：
NIR触发顺序响应纳米载体放大了化学光动力疗法与启发性抗肿瘤免疫的级联协同效应。
理想的癌症治疗策略被认为具有不仅发挥最大的抗癌能力而且激发抗肿瘤免疫力以防止肿瘤复发和转移的有效能力。在这项研究中，准备了由ROS反应性胶束包裹的多功能上转换纳米粒子（UCNP），用于肿瘤靶向和近红外（NIR）触发的光动力疗法（PDT）联合化疗的协同效应。此外，PDT和化学治疗剂均可通过诱导CD8 +和CD4 +引起的免疫原性细胞死亡来激活抗肿瘤免疫力T细胞浸润在肿瘤中。通过实验，通过级联放大化学PDT和系统性抗肿瘤免疫作用，在无创NIR辐射下静脉内施用多功能纳米载体可破坏原位肿瘤并有效抑制转移性三阴性乳腺癌模型中的肺转移。总之，本研究为转移性癌症治疗提供了具有启发性的抗肿瘤免疫力的前瞻性化学PDT。
更新日期：2020-07-22
中文翻译：
NIR触发顺序响应纳米载体放大了化学光动力疗法与启发性抗肿瘤免疫的级联协同效应。
理想的癌症治疗策略被认为具有不仅发挥最大的抗癌能力而且激发抗肿瘤免疫力以防止肿瘤复发和转移的有效能力。在这项研究中，准备了由ROS反应性胶束包裹的多功能上转换纳米粒子（UCNP），用于肿瘤靶向和近红外（NIR）触发的光动力疗法（PDT）联合化疗的协同效应。此外，PDT和化学治疗剂均可通过诱导CD8 +和CD4 +引起的免疫原性细胞死亡来激活抗肿瘤免疫力T细胞浸润在肿瘤中。通过实验，通过级联放大化学PDT和系统性抗肿瘤免疫作用，在无创NIR辐射下静脉内施用多功能纳米载体可破坏原位肿瘤并有效抑制转移性三阴性乳腺癌模型中的肺转移。总之，本研究为转移性癌症治疗提供了具有启发性的抗肿瘤免疫力的前瞻性化学PDT。
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