Abstract

In this work, the new diaminochromenes: 2,5-dimono-8-methoxychromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile (4), 8-ethoxy-2-imino-3,4-dihydro-2H-chromene-3-carbonitrile-4-malononitrile (5), 2,5-diamino-8-ethoxychromene[4,3,2-de][1,6]naphthyridine-4-carbonotrile (6), were synthesized and fully characterized through 600 MHz using ¹H, ¹³C, APT, gHSQC, gHMBC, ROESY-1D and gated decoupling ¹³C. Further docking studies suggested that these compounds are capable of intercalating with the Drew-Dickerson Dodecamer DNA and, therefore, be candidates to work as effective compounds to decrease the cancer radiotherapy.

Communicated by Ramaswamy H. Sarma

摘要

在这项工作中，新的二氨基色烯：2,5-dimono-8-methoxychromeno[4,3,2- de ][1,6] naphthyridine-4-carbonitrile ( 4 ), 8-ethoxy-2-imino-3, 4-dihydro-2 H -chromene-3-carbonitrile-4-malononitrile ( 5 ), 2,5-diamino-8-ethoxychromene[4,3,2- de ][1,6]naphthyridine-4-carbonotrile ( 6 )，使用¹ H、¹³ C、APT、gHSQC、gHMBC、ROESY-1D 和门控去耦通过 600 MHz 合成并完全表征¹³C. 进一步的对接研究表明，这些化合物能够嵌入 Drew-Dickerson Dodecamer DNA，因此可以作为有效化合物减少癌症放射治疗。

由 Ramaswamy H. Sarma 交流