ABSTRACT

Ethanol intoxication increases oxidative stress and pro-inflammatory proteins, which cause neurodegeneration. Morin is a natural flavonoid obtained from plants of the Moraceae family that exhibits antioxidant, anti-inflammatory, hepatoprotective, anticancer and cardioprotective properties. We investigated the neuroprotective effect of morin on ethanol intoxicated rats. Rats exposed to ethanol exhibit increased cholesterol, triglycerides, phospholipids, free fatty acids, and lipid oxidative byproducts, and decreased the activity of antioxidant enzymes and membrane ATPase. We found that ethanol increased activation of microglia and astrocytes in the brain. Administration of morin to rats exposed to ethanol significantly decreased lipid oxidative byproducts, enhanced antioxidant enzymes, normalized lipid levels and decreased microglia and astrocyte activation. Morin exhibits neuroprotective properties against ethanol intoxication by increasing the antioxidant defense mechanism and decreasing the inflammatory response caused by neuroglia and astrocytes.

摘要

乙醇中毒会增加氧化应激和促炎蛋白，从而导致神经变性。Morin 是一种从桑科植物中提取的天然黄酮类化合物，具有抗氧化、抗炎、保肝、抗癌和保护心脏的特性。我们研究了桑椹对乙醇中毒大鼠的神经保护作用。暴露于乙醇的大鼠表现出胆固醇、甘油三酯、磷脂、游离脂肪酸和脂质氧化副产物增加，并降低抗氧化酶和膜 ATP 酶的活性。我们发现乙醇增加了大脑中小胶质细胞和星形胶质细胞的活化。给暴露于乙醇的大鼠服用桑椹灵显着减少了脂质氧化副产物，增强了抗氧化酶，血脂水平正常化，小胶质细胞和星形胶质细胞活化减少。Morin 通过增加抗氧化防御机制和减少由神经胶质细胞和星形胶质细胞引起的炎症反应，表现出对抗乙醇中毒的神经保护特性。