Abstract Objective The objective of this study is to detect the liver stiffness of hepatitis B virus (HBV)-infected patients with an alanine aminotransferase (ALT) level of <2 upper limit of normal (2ULN) by FibroScan and compare histological changes to assess the progression of liver lesions and its test results. Methods There were 36 patients who had a liver FibroScan degree of >7.3 KD (F1), and a liver biopsy was conducted. Along with serology of liver fibrosis, indexes and hierarchical processing were used for evaluation. The correlation between these factors was analyzed. Results The histopathological results of the liver were closely correlated with liver hardness. In the pathological diagnosis of chronic hepatitis, G represents the grade of inflammation and S represents the stage of hepatic fibrosis. Pathological examination results of H&E staining of liver tissue sections revealed that the area under the work characteristic curve of the subjects in G2S1, G2S2, G3S2, and G3S3 stages was 0.923, 0.916, 0.955, and 0.971, respectively, with diagnostic cut-off values of 9.03, 9.85, 15.14, and 30.67, respectively. Furthermore, hydroxyapatite, type III procollagen, laminin, and type IV collagen of serum fibrosis indexes are associated with liver stiffness values (P < 0.05). Conclusion FibroScan can be used as an alternative to liver biopsy. It is meaningful in determining whether HBV infected patients with an ALT level of <2 ULN should receive antiviral therapy.

中文翻译：

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FibroScan检测在ALT<2正常值上限的HBV感染者抗病毒治疗中的效果


摘要 目的本研究旨在检测丙氨酸转氨酶（ALT）<2 id=0>7.3 KD（F1）的乙型肝炎病毒（HBV）感染者的肝脏硬度，并进行肝活检。 。与肝纤维化血清学一起，使用指标和分层处理进行评估。分析了这些因素之间的相关性。结果肝脏组织病理学结果与肝脏硬度密切相关。慢性肝炎的病理诊断中，G代表炎症分级，S代表肝纤维化阶段。肝组织切片H&E染色病理检查结果显示，G2S1、G2S2、G3S2、G3S3期受试者的工作特性曲线下面积分别为0.923、0.916、0.955、0.971，诊断临界值分别为 9.03、9.85、15.14 和 30.67。此外，血清纤维化指标羟基磷灰石、III型前胶原、层粘连蛋白、IV型胶原与肝脏硬度值相关（P < 0.05）。结论 FibroScan 可作为肝活检的替代方法。这对于确定 ALT 水平<2 ULN 的 HBV 感染患者是否应该接受抗病毒治疗具有重要意义。