Accumulating studies have investigated the PM2.5‐induced pulmonary toxicity, while gaps still remain in understanding its toxic mechanism. Due to its high specific surface area and adsorption capacity similar to nanoparticles, PM2.5 acts as a significant carrier of metals in air and then leads to altered toxic effects. In this study, we aimed to use CBs and Ni as model materials to investigate the autophagy changes and pulmonary toxic effects at 30 days following intratracheal instillation of CBs‐Ni mixture.

中文翻译：

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炭黑-金属离子共暴露30天小鼠肺组织自噬变化

越来越多的研究调查了 PM2.5 引起的肺毒性，但对其毒性机制的理解仍然存在差距。由于其高比表面积和类似于纳米颗粒的吸附能力，PM2.5 在空气中充当金属的重要载体，然后导致毒性作用改变。在本研究中，我们的目的是使用 CBs 和 Ni 作为模型材料，研究气管内滴注 CBs-Ni 混合物后 30 天的自噬变化和肺毒性作用。